Insulin-Like Growth Factor Binding Protein, active 5, active (IGFBP5), Recombinant, Human
Artikelnummer:
USB-348078
Hersteller Artikelnummer:
348078
Alternativnummer:
USB-348078-5
Hersteller:
US Biological
Kategorie:
Molekularbiologie
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit IGF-II induced proliferation of MCF-7 cells is less than 0.4ug/ml, corresponding to a specific activity of >2500 IU/mg in the presence of 15ng/ml of rHuIGF-II. Sequence: LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK LPGMEYVDGD FQCHTFDSSN VE Molecular Weight: 28.6kD PubMed ID: 1850258, 1709938, 7511611, 15489334, 1850257, 9883900, 22117064, 260910e39, 9822601 Gene Name: IGFBP5, IBP5 Swiss Prot: P24593 Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
