Mesencephalic astrocyte-derived neurotrophic factor, active (MANF), Recombinant, Human
Artikelnummer:
USB-348173
Hersteller Artikelnummer:
348173
Alternativnummer:
USB-348173-5
Hersteller:
US Biological
Kategorie:
Molekularbiologie
Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Full-length recpmbinant protein corresponding to aa25-182 from human MANF, expressed in E. coli. Swiss/UniProt: P55145 Amino Acid Sequence: LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKIL DDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL Molecular Weight: 18.2kD PubMed ID: 8649854, 15489334, 16641997, 12665801, 12794311, 15144186, 18561914, 21269460, 24275569, 19258449, 8971156, 9174057 Gene Name: MANF, ARMET, ARP Swiss Prot: P55145 Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
