CCN1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. The function of this cyclin has not yet been determined. Source: Recombinant protein corresponding to aa1-377 of human CCN1, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~44.9kD Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSMKFPGPL ENQRLSFLLE LASSLLDRFL ATVKAHPKYL SCIAISCFFL AAKTVEEDER AVSTRPQLLF SLPKLSPSQH LAVLTKQLLH CMACNQLLQF STLQSSLPLN SVYVYRPLKH TLVTCDKGVF RLHPSSVPGP KRLYNEDNVS ENVGSVCGTD LSRQEGHASP CPPLQPVSVM KAITREAQMW KVNVRKMPSN QNVSPSQRDE VIQWLAKLKY QFNLYPETFA IPVLKVLARD SFCGCSSSEI LRMERIILDK LNWDLHTATP LDFLHIFHAI RGSMLALAMV SLEMEKLIPD WLSLTIELLQ KAQMDSSQLI HCRELVAHHL DFSKDNSKPE VPVRGTAAFY HHLPAASGCK QTSTKRKVEE MEVDDFYDGI Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
