CDKN2C, Recombinant, Human, aa1-168, His-Tag (Cyclin-dependent kinase 4 inhibitor C)

Produktübersicht

• Artikelname: CDKN2C, Recombinant, Human, aa1-168, His-Tag (Cyclin-dependent kinase 4 inhibitor C)
• Artikelnummer: USB-349778
• Hersteller Artikelnummer: 349778
• Alternativnummer: USB-349778-100, USB-349778-500
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

CDKN2C (Cyclin-dependent kinase 4 inhibitor C ) belongs to the CDKN2 cyclin-dependent kinase inhibitor family. It has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. And this protein suppresses the cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Recombinant protein corresponding to aa1-168 of human CDKN2C, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~20.7kD (MALDI-TOF) Amino Acids Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMAEPWG NELASAAARG DLEQLTSLLQ NNVNVNAQNG FGRTALQVMK LGNPEIARRL LLRGANPDLK DRTGFAVIHD AARAGFLDTL QTLLEFQADV NIEDNEGNLP LHLAAKEGHL RVVEFLVKHT ASNVGHRNHK GDTACDLARL YGRNEVVSLM QANGAGGATN LQ Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 20.7
• NCBI: 001253
• UniProt: P42773
• Reinheit: 95% (SDS-PAGE). Purified by using conventional chromatography techniques.
• Formulierung: Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 2mM DTT, 200mM sodium chloride, 10% glycerol.