NF-kappa-B inhibitor delta, also known as NFKBID, is a member of the IkB family of proteins can be divided into four groups (IkB-alpha, IkB-beta, IkB-gamma, IkB-epsilon). NFKBID plays a role in the regulation of both inflammatory responses and cytokine, IL-2 and IL-6 expression via NFkB activity. Existing as three alternatively spliced isoforms, NFKBID associates with RelB, NFkB p50 and NFkB p65 in nucleus, and is thought to assist in thymocyte selection in response to TCR induction. Source: Recombinant protein corresponding to aa1-313 of human NFKBID, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~35.9kD Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSMEAGPWR VSAPPSGPPQ FPAVVPGPSL EVARAHMLAL GPQQLLAQDE EGDTLLHLFA ARGLRWAAYA AAEVLQVYRR LDIREHKGKT PLLVAAAANQ PLIVEDLLNL GAEPNAADHQ GRSVLHVAAT YGLPGVLLAV LNSGVQVDLE ARDFEGLTPL HTAILALNVA MRPSDLCPRV LSTQARDRLD CVHMLLQMGA NHTSQEIKSN KTVLHLAVQA ANPTLVQLLL ELPRGDLRTF VNMKAHGNTA LHMAAALPPG PAQEAIVRHL LAAGADPTLR NLENEQPVHL LRPGPGPEGL RQLLKRSRVA PPGLSS Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
