NuDT2 is a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NuDIX hydrolase family. This protein maintains homeostasis by using water to cleave the metabolite NuDT symmetrically back into its original ATP and AMP molecules. NuDT2 is also active towards other adenosine and diadenosine polyphosphates with four or more phosphate groups, but not towards diadenosine triphosphate. NuDT2 is involved in heat shock and metabolic stress by regulating intracellular dinucleoside polyphosphate concentrations. Source: Recombinant protein corresponding to aa1-147 of human NuDT2, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~19.0kD Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MALRACGLII FRRCLIPKVD NNAIEFLLLQ ASDGIHHWTP PKGHVEPGED DLETALRETQ EEAGIEAGQL TIIEGFKREL NYVARNKPKT VIYWLAEVKD YDVEIRLSHE HQAYRWLGLE EACQLAQFKE MKAALQEGHQ FLCSIEA Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
