S100 calcium binding protein A6 (S100A6) belongs to the S100 family. S100 family is containing 2 EF-hand calcium-binding motifs. S100 proteins regulate a number of cellular processes such as cell cycle progressions and differentiation. S100A6 plays a role in the reorganization of the actin cytoskeleton and in cell mobility. This is a specific target of S-100B protein in vivo. The binding of S100A6 to S100B is stabilized by S100B-bound calcium and zinc. It associates with both Annexin XI and CacyBP (Calcyclin-binding protein). It functions to activate several processes along the calcium signal transduction pathway including the regulation of cell growth, proliferation, secretion and exocytosis. Source: Recombinant protein corresponding to aa1-89 of mouse S100A6, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~12.2kD Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MACPLDQAIG LLVAIFHKYS GKEGDKHTLS KKELKELIQK ELTIGSKLQD AEIARLMDDL DRNKDQEVNF QEYVAFLGAL ALIYNEALK Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
