SH3BGRL, also known as SH3 domain-binding glutamic acid-rich-like protein, is a member of the human SH3BGR family. SH3BGRL gene located to chromosome Xq13.3 encodes for a small protein of 114aa, which is apparently widely expressed in many tissues including liver and blood. SH3BGRL protein features a prolinerich sequence (PLPPQIF), which contains both the SH3 binding (PXXP)3 and the Homer EVH1 binding (PPXXF)4 motif. This proline-rich region is highly conserved in human SH3BGR family and was expected to be functionally important. Source: Recombinant protein corresponding to aa1-114 of human SH3BGRL, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~15.3kD Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMVIRVY IASSSGSTAI KKKQQDVLGF LEANKIGFEE KDIAANEENR KWMRENVPEN SRPATGYPLP PQIFNESQYR GDYDAFFEAR ENNAVYAFLG LTAPPGSKEA EVQAKQQA Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
