TSSC4 (tumor suppressing subtransferable candidate 4), also known as tumor suppressing STF cDNA 4 protein, belongs to the TSSC4 family. This protein is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith- Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. It plays a role in malignancies and disease that involve this region as well as hematopoietic cell function This protein was widely expressed in nearly all adult tissues, TSSC4 is also found in fetal liver, lung, kidney and brain. Recombinant protein corresponding to aa1-329 of human TSSC4, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~36.8kD (MALDI-TOF) (Molecular weight on SDS-PAGE will appear higher) Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMAEAGT GEPSPSVEGE HGTEYDTLPS DTVSLSDSDS DLSLPGGAEV EALSPMGLPG EEDSGPDEPP SPPSGLLPAT VQPFHLRGMS STFSQRSRDI FDCLEGAARR APSSVAHTSM SDNGGFKRPL APSGRSPVEG LGRAHRSPAS PRVPPVPDYV AHPERWTKYS LEDVTEVSEQ SNQATALAFL GSQSLAAPTD CVSSFNQDPS SCGEGRVIFT KPVRGVEARH ERKRVLGKVG EPGRGGLGNP ATDRGEGPVE LAHLAGPGSP EAEEWGSPHG GLQEVEALSG SVHSGSVPGL PPVETVGFHG SRKRSRDHFR NKSSSPEDPG AEV Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
