VSTM2L, also known as V-set and transmembrane domain containing 2, is a new modulator of HN neuroprotective activity. It colocalizes with HN in distinct brain areas as well as in primary cultured neurons, where it plays a role in the modulation of neuronal viability. When tested in HN neuroprotection bioassays, it acts as a strong antagonist of HN neuroprotective activity. This protein is the first example of a secreted antagonist of HN and may play a role in the modulation of HN biological functions. Source: Recombinant protein corresponding to aa25-204 of human VSTM2L, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~22.6kD AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMTRPAG HAPWDNHVSG HALFTETPHD MTARTGEDVE MACSFRGSGS PSYSLEIQWW YVRSHRDWTD KQAWASNQLK ASQQEDAGKE ATKISVVKVV GSNISHKLRL SRVKPTDEGS YECRVIDFSD GKARHHKVKA YLRVQPGENS VLHLPEAPPA APAPPPPKPG KELRKRSVDQ EACSL Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
