KAT2A, CT (GCN5, Histone Acetyltransferase KAT2A, K(lysine) acetyltransferase 2A, General control of amino acid synthesis protein 5-like 2, Histone acetyltransferase GCN5, GCN5L2, HGCN5), Rabbit
Artikelnummer:
USB-350698
Hersteller Artikelnummer:
350698
Alternativnummer:
USB-350698-100
Hersteller:
US Biological
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Immunogen:
Synthetic peptide corresponding to aa75-106 DPARPGLSQQQRASQRKAQVRGLPRAKKLEKL of human KAT2A/GCN5 at C-terminal.
Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the KAT2A gene. It is mapped to 17q21. KAT2A, or GCN5, GCN5L2, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. The GCN5 protein, a regulator of transcription activation in yeast, promotes maximal levels of transcription by 2 transcriptional activators, GCN4 and the HAP2-HAP3-HAP4 complex. The GCN4 protein activates transcription of a large number of amino acid biosynthetic genes under limiting amino acid conditions and the HAP2-HAP3-HAP4 complex is thought to mediate transcription of genes involved in respiratory functions. GCN5 also functions as a repressor of NF-kappa-B by promoting ubiquitination of the NF-kappa-B subunit RELA in a HAT- independent manner. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.1-0.5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
