CD36, also known as platelet glycoprotein 4, is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types. As a member of the scavenger receptor family, CD36 is a multiligand pattern recognition receptor that interacts with a large number of structurally dissimilar ligands. It plays a role in lipid metabolism and has been identified as a fatty acid translocase necessary for the binding and transport of LCFA in cells and tissues. It also plays a significant role in the initiation and pathogenesis of chronic inflammatory diseases such as Alzheimers disease and atherosclerosis. It is an integral membrane protein primarily serving as receptors for thrombospondin and collagen and by the erythrocytes infected with the human malaria parasite. Recombinant protein corresponding to aa30-439 from mouse CD36, fused to His-tag at C-terminal expressed in insect cell. Molecular Weight: ~47.4kD (419aa) Amino Acid Sequence: ADPGDMLIEK TIKREVVLEE GTTAFKNWVK TGTTVYRQFW IFDVQNPDDV AKNSSKIKVK QRGPYTYRVR YLAKENITQD PEDHTVSFVQ PNGAIFEPSL SVGTEDDNFT VLNLAVAAAP HIYQNSFVQV VLNSLIKKSK SSMFQTRSLK ELLWGYKDPF LSLVPYPIST TVGVFYPYND TVDGVYKVFN GKDNISKVAI IESYKGKRNL SYWPSYCDMI NGTDAASFPP FVEKSRTLRF FSSDICRSIY AVFGSEIDLK GIPVYRFVLP ANAFASPLQN PDNHCFCTEK VISNNCTSYG VLDIGKCKEG KPVYISLPHF LHASPDVSEP IEGLHPNEDE HRTYLDVEPI TGFTLQFAKR LQVNILVKPA RKIEALKNLK RPYIVPILWL NETGTIGDEK AEMFKTQVTG KIKHHHHHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
