CD40LG, also known as CD40 ligand, belongs to the tumor necrosis factor family. This protein binds to TNFRSF5. CD40LG mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. CD40 ligand dysregulation on T cells and antigen presenting cells contributes to the immune deficiency associated with HIV infection and AID Recombinant protein corresponding to aa112-260 from mouse CD40LG, fused to His-tag at C-terminal expressed in insect cell. Molecular Weight: ~17.2kD (155aa) Amino Acid Sequence: MQRGDEDPQI AAHVVSEANS NAASVLQWAK KGYYTMKSNL VMLENGKQLT VKREGLYYVY TQVTFCSNRE PSSQRPFIVG LWLKPSSGSE RILLKAANTH SSSQLCEQQS VHLGGVFELQ AGASVFVNVT EASQVIHRVG FSSFGLLKLH HHHHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
