MRG-binding protein, also known as MRGBP, is a 204aa protein which is a part of the NuA4 histone acetyltransferase (HAT) complex that acts to acetylate histone H2A and H4. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. MRGBP has potential to interact with MORF4L1/MRG15 and MORF4L2/MRGX. Recombinant protein corresponding to aa1-204 from human MRGBP, fused to His-tag at N-terminal, expressed in E. coli. Molecular Weight: ~24.5kD (224aa) AA Sequence: MGSSHHHHHH SSGLVPRGSH MGEAEVGGGG AAGDKGPGEA ATSPAEETVV WSPEVEVCLF HAMLGHKPVG VNRHFHMICI RDKFSQNIGR QVPSKVIWDH LSTMYDMQAL HESEILPFPN PERNFVLPEE IIQEVREGKV MIEEEMKEEM KEDVDPHNGA DDVFSSSGSL GKASEKSSKD KEKNSSDLGC KEGADKRKRS RVTDKVLTAN SNPSSPSAAK RRRT Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
