Methionine sulfoxide reductase B3, also known as MSRB3, belongs to the methionine sulfoxide reductases (MSR) family proteins. MSRs are thought to protect against reactive oxygen species-induced oxidative damage in many organs, including the most environmentally exposed organ, human skin. MSRB3 plays an important role in cold tolerance by eliminating MetO and ROS that accumulate at the ER during cold acclimation. Recombinant protein corresponding to aa21-185 from human MSRB3, fused to His-tag at C-terminal, expressed in E. coli. Molecular Weight: ~19kD (174aa) Amino Acid Sequence: MCGLPSGSCR DKKNCKVVFS QQELRKRLTP LQYHVTQEKG TESAFEGEYT HHKDPGIYKC VVCGTPLFKS ETKFDSGSGW PSFHDVINSE AITFTDDFSY GMHRVETSCS QCGAHLGHIF DDGPRPTGKR YCINSAALSF TPADSSGTAE GGSGVASPAQ ADKAELLEHH HHHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
