LFA1a (Lymphocyte Function Associated Antigen 1 Alpha, CD11a, ITG-AL, LFA-1, LFA1-A, ITGAL, Integrin, Alpha L, CD11 antigen-like family member A, Leukocyte function-associated molecule 1 alpha chain), Rabbit
Artikelnummer:
USB-363955
Hersteller Artikelnummer:
363955
Alternativnummer:
USB-363955-200
Hersteller:
US Biological
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
ELISA, IHC, WB
Immunogen:
Recombinant protein corresponding to Leu788-Glu1004 of rat LFA1a expressed in E. coli.
Integrin, alpha Lis a human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab. ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3, and also functions in lymphocyte costimulatory signaling.CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- LRL MSSASLAVEW TLRNLGEDAY WVRLDLDFPR GLSFRKVEML QPHSQIPVSC EELTEESSLL TKTLKCNVSS PIFKAGKQMT LQVMFNTLLN SSWGDFVELN GTVHCENENS SLGKDNSATT RIPVLYPVNI LTEDQENSTL YISFTPKGPK TQQVQHIYKV RIQPSAYDHN MPALEALVEV PQPHSEGPIA HTWTVHTDPL VTCHCEDLKK PTRE Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
