TICAM1 (Toll Like Receptor Adaptor Molecule 1, TRIF, PRVTIRB, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta, Proline-rich, vinculin and TIR domain-containing protein B), Rabbit
TICAM1 (Toll Like Receptor Adaptor Molecule 1, TRIF, PRVTIRB, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta, Proline-rich, vinculin and TIR domain-containing protein B), Rabbit
TICAM1 (Toll Like Receptor Adaptor Molecule 1, TRIF, PRVTIRB, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta, Proline-rich, vinculin and TIR domain-containing protein B), Rabbit
Artikelnummer:
USB-365296
Hersteller Artikelnummer:
365296
Alternativnummer:
USB-365296-200
Hersteller:
US Biological
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
ELISA, IHC, WB
Immunogen:
Recombinant protein corresponding to Gln443-Gln685 of human TICAM1, expressed in E. coli.
TRIF is primarily active in the spleen and is often regulated when MyD88 is deficient in the liver, indicating organ-specific regulation of signaling pathways. Curiously, there is a lack of redundancy within the TLR4 signaling pathway that leads to microbial evasion of immune response in the host after mutations occur within intermediates of the pathway. Three TRAF-binding motifs present in the amino terminal region of TRIF are necessary for association with TRAF6. Destruction of these motifs reduced the activation of NF-kappa Beta, a transcription factor that is also activated by the carboxy-terminal domain of TRIF in the upregulation of cytokines and co-stimulatory immune molecules. This domain recruits receptor-interacting protein (RIP1) and RIP3 through the RIP homotypic interaction motif. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- QDAIDHSA FIILLLTSNF DCRLSLHQVN QAMMSNLTRQ GSPDCVIPFL PLESSPAQLS SDTASLLSGL VRLDEHSQIF ARKVANTFKP HRLQARKAMW RKEQDTRALR EQSQHLDGER MQAAALNAAY SAYLQSYLSY QAQMEQLQVA FGSHMSFGTG APYGARMPFG GQVPLGAPPP FPTWPGCPQP PPLHAWQAGT PPPPSPQPAA FPQSLPFPQS PAFPTASPAP PQSPGLQPLI IHHAQ Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
