GSK923295 is a potent and selective mitotic kinesin Centromere protein E (CENP-E) inhibitor, a protein that accumulates in the G2 phase of the cell cycle. It is proposed to be one of the motors responsible for mammalian chromosome movement and spindle elongation. GSK923295 induces mitotic arrest and chromosome alignment failure. It is reported to be a potent inhibitor of tumor cell growth, which is further enhanced when MEK/ERK signaling is also inhibited. Synonyms: GSK-923295, 3-chloro-N-[(2S)-1-[[2-(dimethylamino)acetyl]amino]-3-[4-[8-[(1S)-1hydroxyethyl]imidazo[ 1,2-a]pyridin-2-yl]phenyl]propan-2-yl]-4-propan-2-yloxybenzamide CAS Number: 1088965-37-0 Molecular Formula: C32H38ClN5O4 Molecular Weight: 592.1 Purity: 98% Appearance: Crystalline solid Solubility: Soluble in organic solvents such as DMSO. Soluble in DMSO >10mM. Applications: FA Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with organic solvent. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molekulargewicht:
592.1
CAS Nummer:
[1088965-37-0]
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