CD80, Recombinant, Mouse, aa37-246, His-Tag (T-lymphocyte Activation Antigen CD80)
Artikelnummer:
USB-369028
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| Artikelname: | CD80, Recombinant, Mouse, aa37-246, His-Tag (T-lymphocyte Activation Antigen CD80) |
| Artikelnummer: | USB-369028 |
| Hersteller Artikelnummer: | 369028 |
| Alternativnummer: | USB-369028-10,USB-369028-50,USB-369028-100,USB-369028-250 |
| Hersteller: | US Biological |
| Kategorie: | Molekularbiologie |
| Cd80, also known as T-lymphocyte activation antigen CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: Cd28 (for autoregulation and intercellular association) and Ctla4 (for attenuation of regulation and cellular disassociation). This protein also plays a role in induction of innate immune responses by activating NF-KB-signaling pathway in macrophages. It is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. Recombinant protein corresponding to aa37-246 from mouse Cd80, fused to His-Tag at C-terminal, expressed in insect cell. Swiss/Accession Number: Q00609 Molecular Weight: ~24.7kD (216aa) 28-40kD (SDS-PAGE under non-reducing conditions) Amino Acid Sequence: DVDEQLSKSV KDKVLLPCRY NSPHEDESED RIYWQKHDKV VLSVIAGKLK VWPEYKNRTL YDNTTYSLII LGLVLSDRGT YSCVVQKKER GTYEVKHLAL VKLSIKADFS TPNITESGNP SADTKRITCF ASGGFPKPRF SWLENGRELP GINTTISQDP ESELYTISSQ LDFNTTRNHT IKCLIKYGDA HVSEDFTWEK PPEDPPDSKN HHHHHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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