MEP1A, Recombinant, Human, aa22-601, His-Tag (Meprin A Subunit alpha)
Artikelnummer:
USB-369098
Hersteller Artikelnummer:
369098
Alternativnummer:
USB-369098-10
Hersteller:
US Biological
Kategorie:
Molekularbiologie
MEP1A, also known as meprin A subunit alpha, is a single-pass type I membrane protein which belongs to the peptidase M12A family. It abundantly expressed in kidney and intestinal epithelial cells, are secreted into the urinary tract and intestinal lumen, and are found in leukocytes and cancer cells under certain conditions. It is capable of proteolytically degrading extracellular matrix proteins, proteolytically processing bioactive proteins, and play a role in inflammatory processes. Source: Recombinant protein corresponding to aa22-601 from human MEP1A, fused to His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~67.4kD (589aa) 70-100kD (SDS-PAGE under reducing conditions) Amino Acid Sequence: ADPVPIKYLP EENVHDADFG EQKDISEINL WSEVGDQHVG QNISIGQGCA YKAIIEHEIL IGQRLDFSAI DLERLNRMYN CTTTHTLLDH KMTGSPSDRL VVWVRRDDST GNVRKLVKVQ FYNSEGYGFG VTLYPNSRES SGYLRLAFHV GFISHQMLKR RSFLKNDDLI IFVDFEDITH AAGLDLFQGD ILLQKSRNGL RDPNTRWTFP IPYILADNLG LNAKGAILYA FEMFRLKSCV DFKPYEGESS YIIFQQFDGC HALGFYHEQS RTDRDDYVNI WWDQILSGYQ HNFDTYDDSL ITDLNTPYDY ESLMHYQPFS FNKNASVPTI TAKIPEFNSI CTFEKANICG MIQGTRDDTD WAHQDSAQAG EVDHTLLGQC TGAGYFMQFS TSSGSAEEAA LLESRILYPK RKQQCLQFFY TFQGDDDHNW KIAHVVLKEE QKFRYLFQGT KGDPQNSTGG IYLDDITLTE TPCPTGVWTV RNFSQVLENT SKGDKLQSPR CSGENDAILE WPVENRQVII TILDQEPDVR NRMSSSMVFT TSKSHTSPAI NDTVIWDRPS RVGTYHTDCN CFRSIDLGWS LSQHHHHHH Endotoxin: ~1EU/1ug (LAL) Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
