PLAUR, as known as urokinase plasminogen activator surface receptor isoform 1, is one of two activators that converts the extracellular zymogen plasminogen to plasmin, a serine protease that is involved in a variety of normal and pathological processes that require cell migration and/or tissue destruction. This protein is synthesized and released from cells as a single-chain proenzyme with limited enzymatic activity and is converted to an active two-chain disulfide-linked active enzyme by plasmin and other specific proteinases. Source: Recombinant protein corresponding to aa23-305 from human PLAUR, fused to His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~32.5kD (291aa) 40-57kD (SDS-PAGE under reducing conditions) Endotoxin: ~1EU/1ug (LAL) Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
