TLR2, as known as toll-like receptor 2, belongs to the toll-like receptor (TLR) family. Human TLR family includes the members that activate the innate immune response via an ability to recognize molecular structures found in a variety of microbial pathogens. Specially, this protein is highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. It functions as part of a heterodimeric complex with either TLR1 or TLR6, and possibly other co-receptors. Source: Recombinant protein corresponding to aa19-588 from human TLR2, fused to His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~65.5kD (578aa) 50-70kD (SDS-PAGE under reducing conditions.) Endotoxin: ~1EU/1ug (LAL) Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
