PPARG, Recombinant, Human, aa1-477, His-Tag (Peroxisome Proliferator-activated Receptor gamma, Nuclear Receptor Subfamily 1 Group C Member 3)

Produktübersicht

• Artikelname: PPARG, Recombinant, Human, aa1-477, His-Tag (Peroxisome Proliferator-activated Receptor gamma, Nuclear Receptor Subfamily 1 Group C Member 3)
• Artikelnummer: USB-370754
• Hersteller Artikelnummer: 370754
• Alternativnummer: USB-370754-20,USB-370754-100,USB-370754-1
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

Nuclear receptor that binds peroxisome proliferators such as hypolipidic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elents (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels. Source: Recombinant protein corresponding to aa1-477 from human PPARG, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~70.3kD Amino Acid Sequence: MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 70.3
• UniProt: P37231
• Reinheit: 90% (SDS-PAGE)
• Formulierung: Supplied as a lyophilized powder from 20mM Tris-HCl, 0.5M sodium chloride, pH 8.0, 6% trehalose. Reconstitute with sterile ddH2O to a concentration of 0.1-1mg/ml.