STAT3, Recombinant, Human, aa50-240, His-SUMO-Tag (Signal Transducer and Activator of Transcription 3)

Produktübersicht

• Artikelname: STAT3, Recombinant, Human, aa50-240, His-SUMO-Tag (Signal Transducer and Activator of Transcription 3)
• Artikelnummer: USB-375432
• Hersteller Artikelnummer: 375432
• Alternativnummer: USB-375432-20,USB-375432-100,USB-375432-1
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic domain STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G. Source: Recombinant protein corresponding to aa50-240 from human STAT3, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~38.3kD Amino Acid Sequence: ESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 38.3
• UniProt: P40763
• Reinheit: 90% (SDS-PAGE)
• Formulierung: Supplied as a lyophilized powder from 20mM Tris-HCl, 0.5M sodium chloride, pH 8.0, 6% trehalose. Reconstitute with sterile ddH2O to a concentration of 0.1-1mg/ml.