Ybx1, Recombinant, Mouse, aa2-322, His-Tag (Nuclease-sensitive Element-binding Protein 1)

Produktübersicht

• Artikelname: Ybx1, Recombinant, Mouse, aa2-322, His-Tag (Nuclease-sensitive Element-binding Protein 1)
• Artikelnummer: USB-375888
• Hersteller Artikelnummer: 375888
• Alternativnummer: USB-375888-20,USB-375888-100
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

Mediates pre-mRNA alternative splicing regulation. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes Cytoplasmic domain mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. Binds to promoters that contain a Y-box (5-CTGATTGGCCAA-3), such as HLA class II genes. Regulates the transcription of numerous genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at Lys-6 and Lys-7. Binds preferentially to 5-[CU]CUGCG-3 motif in vitro. The secreted form acts as an Extracellular domain mitogen and stimulates cell migration and proliferation. Source: Recombinant protein corresponding to aa2-322 from mouse Ybx1, fused to His-Tag at N-terminal, expressed in Yeast. Molecular Weight: ~37.6kD Amino Acid Sequence: SSEAETQQPPAAPAAALSAADTKPGSTGSGAGSGGPGGLTSAAPAGGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYARRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 37.6
• UniProt: P62960
• Reinheit: 90% (SDS-PAGE)
• Formulierung: Supplied as a lyophilized powder from 20mM Tris-HCl, 0.5M sodium chloride, pH 8.0, 6% trehalose. Reconstitute with sterile ddH2O to a concentration of 0.1-1mg/ml.