PDCD1, Recombinant, Human, aa21-170, hIgG-His-Tag (Programmed Cell Death Protein 1, CD279, hPD-1, hPD-l, hSLE1, PD-1, PD1, SLEB2)
Artikelnummer:
USB-377913
Hersteller Artikelnummer:
377913
Alternativnummer:
USB-377913-50
Hersteller:
US Biological
Kategorie:
Molekularbiologie
PDCD1, also known as programmed cell death protein 1, is a type 1 transmembrane glycoprotein, and is an immune-receptor belonging to the CD28/CTLA4 family. This protein is expressed on the surface of activated T-cell, B-cell, macrophages, myeloid cells and subset of thymocytes. Also, it inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4 and IL-10. As a cell surface molecule, it regulates the adaptive immune response. Source: Recombinant protein corresponding to aa21-170 from human PDCD1, fused to hIgG-His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~44kD (392aa), 40-57kD (SDS-PAGE under reducing conditions.) Endotoxin: <1EU/1ug (determined by LAL method) AA Sequence: ADPPGWFLDS PDRPWNPPTF SPALLVVTEG DNATFTCSFS NTSESFVLNW YRMSPSNQTD KLAAFPEDRS QPGQDCRFRV TQLPNGRDFH MSVVRARRND SGTYLCGAIS LAPKAQIKES LRAELRVTER RAEVPTAHPS PSPRPAGQFQ TLVLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
