AZD-3514, CAS [[1240299-33-5]]

Produktübersicht

• Artikelname: AZD-3514, CAS [[1240299-33-5]]
• Artikelnummer: USB-378280
• Hersteller Artikelnummer: 378280
• Alternativnummer: USB-378280-10,USB-378280-25
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

AZD-3514 is a potent androgen receptor downregulator with potential anticancer cancer activity. Removal of the basic piperazine nitrogen atom, introduction of a solubilising end group and partial reduction of the triazolopyridazine moiety in the previously-described lead androgen receptor downregulator 6-[4-(4-cyanobenzyl)piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine (1) addressed hERG and physical property issues, and led to clinical candidate 6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine (12), designated AZD3514, that is being evaluated in a Phase I clinical trial in patients with castrate-resistant prostate cancer. Synonyms: 1-(4-(2-(4-(1-(3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)piperazin-1-yl)ethanone, 6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine CAS Number: 1240299-33-5 Molecular Formula: C25H32F3N7O2 Molecular Weight: 519.56 Purity: 98% Solubility: Alcohol: 100mg/mL (192.47mM), DMSO: 100mg/mL (192.47mM), Water: Insoluble Storage: -20C

Produkteigenschaften

• Molekulargewicht: 519.56
• Reinheit: 98%
• CAS Nummer: [1240299-33-5]