BSG, also known as basigin isoform 2, is a type 1 transmembrane protein with various different N- and O- glycosylation that belongs to the immunoglobulin superfamily. As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, it is thought also to play a role in intercellular recognition. This protein has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins and regulates several distinct functions, such as spermatogenesis, expression of the mono-carboxylate transporter and the responsiveness of lymphocytes. Also, it induces the production and release of matrix metalloproteinases in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Source: Recombinant protein corresponding to aa22-207 from human BSG, fused to hIgG-His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~47.5kD (428aa), ~40-57kD (SDS-PAGE under reducing conditions) Amino Acid Sequence: ADPAAGTVFT TVEDLGSKIL LTCSLNDSAT EVTGHRWLKG GVVLKEDALP GQKTEFKVDS DDQWGEYSCV FLPEPMGTAN IQLHGPPRVK AVKSSEHINE GETAMLVCKS ESVPPVTDWA WYKITDSEDK ALMNGSESRF FVSSSQGRSE LHIENLNMEA DPGQYRCNGT SSKGSDQAII TLRVRSHLAL EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
