KLRD1, also known as natural killer cells antigen CD94 isoform 1, is expressed on the surface of natural killer cells in the innate immune system. It plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. This protein can form disulfide-bonded heterodimer with NKG2 family members. CD94 and NKG2 complex interacts with Human Leukocyte Antigen (HLA)-E on target cells on the surface of natural killer cells. Recombinant human KLRD1, fused to His-tag at C-terminal, was expressed in insect cell and purified by using conventional chromatography techniques. Source: Recombinant protein corresponding to aa32-179 of human KLRD1, fused to His-tag at C-terminal, expressed in insect cell. Molecular Weight: ~18.2kD (157aa), ~18-28kD (SDS-PAGE under reducing conditions) Endotoxin: <1EU/1ug (determined by LAL method) AA Sequence: ADPKNSFTKL SIEPAFTPGP NIELQKDSDC CSCQEKWVGY RCNCYFISSE QKTWNESRHL CASQKSSLLQ LQNTDELDFM SSSQQFYWIG LSYSEEHTAW LWENGSALSQ YLFPSFETFN TKNCIAYNPN GNALDESCED KNRYICKQQL IHHHHHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
