LAMP1, also known as lysosome-associated membrane glycoprotein 1, is a membrane protein that belongs to the LAMP family. It is expressed in the endosome-lysosome membranes of cells, but is also found on the plasma membrane during the activation of NK cells, CD8+ T cells, mast cells, basophils, monocytes, and platelets. A glycoform of LAMP1 is expressed on the surface of activated macrophages where it promotes T cell co- stimulation and a Th1 biased immune response. Recombinant human LAMP1, fused to His-Tag at C-terminal, expressed in insect cell and purified by using conventional chromatography techniques. Source: Recombinant protein corresponding to aa29-382 of human LAMP1, fused to His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~39.4kD (363aa), ~57-70kD (SDS-PAGE under reducing conditions.) Endotoxin: <1EU/1ug (determined by LAL method) AA Sequence: ADPAMFMVKN GNGTACIMAN FSAAFSVNYD TKSGPKNMTF DLPSDATVVL NRSSCGKENT SDPSLVIAFG RGHTLTLNFT RNATRYSVQL MSFVYNLSDT HLFPNASSKE IKTVESITDI RADIDKKYRC VSGTQVHMNN VTVTLHDATI QAYLSNSSFS RGETRCEQDR PSPTTAPPAP PSPSPSPVPK SPSVDKYNVS GTNGTCLLAS MGLQLNLTYE RKDNTTVTRL LNINPNKTSA SGSCGAHLVT LELHSEGTTV LLFQFGMNAS SSRFFLQGIQ LNTILPDARD PAFKAANGSL RALQATVGNS YKCNAEEHVR VTKAFSVNIF KVWVQAFKVE GGQFGSVEEC LLDENSMHHH HHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
