Nalfurafine is a kappa-opioid receptor (KOR) agonist (EC50 = 0.05nM for human receptors expressed in CHO cell membranes).1 It is selective for kappa-opioid over µ- and delta-opioid receptors (EC50s = 0.72 and 74.1nM, respectively). Nalfurafine (30ug/kg) reduces scratching behavior induced by chloroquine in mice, as well as locomotor activity when administered at a dose of 100ug/kg.2 In rats, nalfurafine (0.01mg/kg) reduces intracranial self-stimulation, lactic acid-induced stretching behavior, and scratching behavior induced by intradermal administration of serotonin .3 Nalfurafine is also an orexin 1 receptor (OX1R) antagonist (Ki = 250nM).4 Synonyms: (2E)-N-[(5alpha,6beta)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-2-propenamide, TRK-820 CAS Number: 152657-84-6 Molecular Formula: C28H32N2O5 Molecular Weight: 476.56 Appearance: White to off-white solid Purity: 95% Melting Point: 165-167C Solubility: DMSO (Slightly), Methanol (Slightly) Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
476.56
Reinheit:
95%
Formulierung:
White to off-white solid
CAS Nummer:
[152657-84-6]
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