3-(1H-1,2,3-Triazol-4-yl)pyridine is a reactant used in the synthesis of 4-aryl-1H-1,2,3-triazoles which possesses more Indoleamine 2,3-dioxygenase (IDO) inhibitory potency than the most commonly used 1-methyltryptophan. 3-TYP is an inhibitor of SIRT3. Sirtuins are a family of highly evolutionarily conserved nicotinamide adenine nucleotide-dependent histone deacetylases. Sirtuin-3 (SIRT3) is a member of the sirtuin family that is localized primarily to the mitochondria and protects against oxidative stress-related diseases, including myocardial ischemia/reperfusion (MI/R) injury. Melatonin has a favorable effect in ameliorating MI/R injury. We hypothesized that melatonin protects against MI/R injury by activating the SIRT3 signaling pathway. Synonyms: 3-(1H-1,2,3-Triazol-5-yl)pyridine, 1H-1,2,3-Triazole-pyridine CAS No: 120241-79-4 Molecular Formula: C7H6N4 Molecular Weight: 146.15 Purity: (HPLC, TLC) 98% Appearance: White to off-white crystalline or powder Solubility: DMF: 10mg/ml DMF:PBS (pH 7.2) (1:5): 0.16mg/ml Ethanol: 5 mg/ml DMSO: 10mg/ml Melting Point: As reported UV: max: 245nm Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric Analysis Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
146.15
CAS Nummer:
[120241-79-4]
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