Sp-8-bromo-Cyclic AMPS (sodium salt), CAS [[1573115-90-8]]

Produktübersicht

• Artikelname: Sp-8-bromo-Cyclic AMPS (sodium salt), CAS [[1573115-90-8]]
• Artikelnummer: USB-440043
• Hersteller Artikelnummer: 440043
• Alternativnummer: USB-440043-500,USB-440043-1,USB-440043-5
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

Sp-8-bromo-cAMPS is a cell-permeable, cAMP analog that combines an exocyclic sulfur substitution in the axial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.1-2 This configuration pools the structural features of two established cyclic-AMP-dependent protein kinase (PKA) activators, 8-bromo-cAMP and Sp-cAMPS. Sp-8-bromo-cAMPS is a PKA agonist (EC50 = 1.5uM) with improved lipophilicity and is not readily degraded by cyclic nucleotide phosphodiesterases.3-4 Synonyms: (4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-sulfide, monosodium salt, 8-Bromoadenosine 3,5-cyclic Monophosphothioate SP-Isomer Sp-8-bromo-cAMPS CAS Number: 1573115-90-8 Molecular Formula: C10H10BrN5NaO5PSNa Molecular Weight: 446.2 Solubility: A stock solution may be made by dissolving the Sp-8-bromo-cAMPS (sodium salt) in the solvent of choice. Sp-8-bromo-cAMPS (sodium salt) is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of Sp-8-bromo-cAMPS (sodium salt) in these solvents is approximately 0.5, 25, and 30 mg/ml, respectively. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of Sp-8-bromo-cAMPS (sodium salt) can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of Sp-8-bromo-cAMPS (sodium salt) in PBS, pH 7.2, is approximately 10mg/ml. We do not recommend storing the aqueous solution for more than one day. Appearance: Crystalline solid Purity: 98% Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Produkteigenschaften

• Molekulargewicht: 446.2
• Reinheit: 98%
• Formulierung: Crystalline solid
• CAS Nummer: [1573115-90-8]