Alectinib M4 metabolite is the major active metabolite of Alectinib. Alectinib is an anaplastic lymphoma kinase (ALK) inhibitor and is used to treat non-small-cell lung cancer by blocking the activity of anaplastic lymphoma kinase (ALK). Synonyms: 9-Ethyl-6,11-dihydro-8-[4-[(2-hydroxyethyl)amino]-1-piperidinyl]-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile CAS No: 1256585-04-2 Molecular Formula: C28H32N4O2 Molecular Weight: 456.58 Purity: 95% (HPLC) (Typically 98%) Appearance: Pale beige solid 1H NMR (DMSO-d6), FT-IR, MS: Conforms to reference Elemental Analysis: (Found) %C: 69.19, %H: 7.31, %N: 11.51, (Calculated) %C: 73.66, %H: 7.06, %N: 12.27 TLC Conditions: SiO2, Dichloromethane : Methanol : Ammonium Hydroxide = 9 : 1 : 0.1, Visualized with UV, AMCS, and KMnO4, Single Spot, Rf = 0.25. Melting Point: >234C (dec.) Solubility: DMSO (Slightly), Methanol (Very Slightly, Heated) Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
456.58
CAS Nummer:
[1256585-04-2]
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