Ascofuranone is an isoprenoid antibiotic originally isolated as a hypolipidemic substance from the phytopathogenic fungus, Ascochyta viciae by researchers at Chugai Pharmaceutical Co., Japan in 1973. Ascofuranone demonstrates antitumor activity against FM3A murine mammary, B16 melanoma and Lewis lung carcinomas. Ascofuranone increases splenic cytotoxicity and phagocytic activity of host animal cells. Ascofuranone targets c-Myc independent of p53. Ascofuranone also inhibits respiration, mitochondrial uptake and glycerol-3-phosphate dehydrogenase. Ascofuranone is active against trypanosomes. Synonyms: 3-Chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3-methyl-7-[(2S)-tetrahydro-5,5-dimethyl-4-oxo-2-furanyl]-2,6-octadien-1-yl]benzaldehyde, [S-(E,E)]-3-Chloro-4,6-dihydroxy-2-methyl-5-[3-methyl-7-(tetrahydro-5,5-dimethyl-4-oxo-2-furanyl)-2,6-octadienyl]-benzaldehyde, Ascofuranone CAS No: 38462-04-3 Molecular Formula: C23H29ClO5 Molecular Weight: 420.93 Appearance: As reported Purity: 95% (HPLC) Melting Point: xxxC Solubility: Soluble in Ethanol, Methanol, DMF or DMSO. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
420.93
Reinheit:
95% (HPLC)
Formulierung:
As reported
CAS Nummer:
[38462-04-3]
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
