Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis. Synonyms: N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (2S)-2-Hydroxybutanedioic Acid, Cabozantinib S-Malate, XL 184 CAS No: 1140909-48-3 Molecular Formula: C28H24FN3O5C4H6O5 Molecular Weight: 635.59 Appearance: White to off-white solid Purity: 98% Melting Point: 166-169C Solubility: DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly) Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
635.59
Reinheit:
98%
Formulierung:
White to off-white solid
CAS Nummer:
[1140909-48-3]
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