Dynole 34-2 is an inhibitor of dynamin (IC50s = 6.9 and 14.2 µM for dynamin 1 and dynamin 2 GTPase activity, respectively).1 It induces multinucleation, inhibits cytokinesis, and induces apoptosis in HeLa cells when used at a concentration of 10uM. Dynole 34-2 inhibits the proliferation of several cancer cell lines (GI50s = 5.8-15uM). Synonyms: 2-cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide CAS No: 1128165-88-7 Molecular Formula: C25H36N4O Molecular Weight: 408.58 Purity: 98% (HPLC) Appearance: Pale yellow to light yellow solid Melting Point: 95-97C (lit) Solubility: Ethanol (50mM), DMSO (100mM). Solution should be purged with an inert gas. Method for Determining Identity: Proton NMR Spectroscopic Analysis and Mass Spectrum Analysis Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at RT. Reconstitute with solvent. Aliquot to avoid repeated freezing and thawing. Store at RT. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molekulargewicht:
408.58
CAS Nummer:
[1128165-88-7]
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