| (-)-Guaiol is a sesquiterpene alcohol that has been found in several traditional Chinese medicinal plants and has antiproliferative, pro-autophagic, insect repellent, and insecticidal biological activities.1,2,3 It selectively inhibits proliferation of A549 and H1299 non-small cell lung carcinoma (NSCLC) cells over BEAS-2B normal lung cells (IC50s = 121.7, 211.5, and 297.1 µM, respectively).1 It also dose-dependently induces formation of DNA double-strand breaks (DSBs) and autophagy in A549 and H1299 cells and increases levels of microtubule-associated protein 1 light chain 3 isoform II (LC3-II). (-)-Guaiol (8 mg/kg three times per week) inhibits tumor growth in an NSCLC mouse xenograft model. It deters A. aegypti and A. quadrimaculatus mosquitoes from feeding on a synthetic blood substitute with a biting-deterrent index (BDI) of 0.82 when used at a concentration of 25 nmol per cm2.2 (-)-Guaiol is also lethal to fourth instar M. separata and third instar P. xylostella larvae (LD50s = 0.07 and 8.9 mg/larva, respectively).3 Synonyms: 1,2,3,4,5beta,6,7,8-Octahydro-alpha,alpha,3alpha,8alpha-tetramethyl-5-azulenemethanol Guai-1(5)-en-11-ol, Guaiol, (3S,5R,8S)-1,2,3,4,5,6,7,8-Octahydro-alpha,alpha,3,8-tetramethyl-5-azulenemethanol, (-)-Guaiol, 3,8-Dimethyl-5-alpha-hydroxyisopropyl-delta9-octahydroazulene, Champaca Camphor, Champacol, Guaiac Alcohol, NSC 19941 CAS No: 489-86-1 Molecular Formula: C15H26O Molecular Weight: 222.37 Appearance: White to off-white solid Purity: 95% Melting Point: 89-91C Solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
