L-Thyroxine-N-methylamide (Levothyroxine N-Methylamide) is an impurity of Thyroxine, one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia. Synonyms: Levothyroxine N-Methylamide, (S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-N-methylpropanamide, alphaS-amino-4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-N-methyl-benzenepropanamide CAS No: 2088032-52-2 Molecular Formula: C16H14I4N2O3 Molecular Weight: 789.91 Appearance: Pale brown to beige solid Purity: 90% Melting Point: >125C (dec.) Solubility: DMF: 10mg/ml, DMSO: 10mg/ml, Ethanol: Slightly soluble, PBS (pH 7.2): 0.20mg/ml Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
789.91
Reinheit:
90%
Formulierung:
Pale brown to beige solid
CAS Nummer:
[2088032-52-2]
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