Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor. Losmapimod is a promising new agent against cardiovascular diseases. This compound works by inhibiting p38 MAP kinases, which play an important role in the development of atherosclerosis and heart failure caused by ischemic conditions. Losmapimod did not cause an improvement in exercise tolerance or lung function, despite being well-tolerated in this COPD population.The p38 MAPK inhibitor losmapimod (GW856553) attenuates the pro-inflammatory response in humans by reducing PIC production. Synonyms: 6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)nicotinamide, GSK-AHAB, GW 856553X, Losmapimod, SB 856553 CAS Number: 585543-15-3 Molecular Formula: C22H26FN3O2 Molecular Weight: 383.46 Appearance: Powder Purity: 98% Melting Point: As reported Solubility: DMSO: 70mg/ml Ethanol: 70mg/ml warmed with 50C water bath Water: Insoluble Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
383.46
Reinheit:
98%
Formulierung:
Powder
CAS Nummer:
[585543-15-3]
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