NOD-like receptor (NLR) pyrin domain-containing protein 3 (NLRP3) senses pathogen-derived, environmental, and host-derived factors and initiates the formation of inflammasomes, complexes involved in complex diseases including multiple sclerosis, type 2 diabetes, Alzheimers disease, and atherosclerosis.1 MCC950 is a selective inhibitor of NLRP3, blocking the release of IL-1beta in macrophages primed with LPS and activated with ATP or nigericin (IC50 = 7.5 nM).2 It does not inhibit NLRC4, AIM2, TLR2 signaling, or priming of NLRP3. MCC950 prevents oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) in cells stimulated with LPS and nigericin.2 MCC-950 is active in vivo, blocking the production of IL-1beta and enhancing survival in mouse models of multiple sclerosis and cryopyrin-associated periodic syndrome.2 It is also active in ex vivo samples from individuals with Muckle-Wells syndrome. Synonym: N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide, CP 456,773 CAS No: 210826-40-7 Molecular Formula: C20H24N2O5S Molecular Weight: 404.48 Appearance: Crystalline solid Purity: 98% Solubility: Soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of MCC950 in ethanol is approximately 0.5 mg/ml and approximately 30 mg/ml in DMSO and DMF. Sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, MCC950 should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. MCC950 has a solubility of approximately 0.5mg/ml in a 1:1 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day. Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
404.48
Reinheit:
98%
Formulierung:
Crystalline solid
CAS Nummer:
[210826-40-7]
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