MF 63 is an anti-inflammatory drug that blocks the action of prostaglandin E2 (PGE2). It is used to treat chronic arthritis and inflammatory diseases, such as Crohns disease. MF 63 has been shown to inhibit nitrite reductase activity in a type strain from Pseudomonas aeruginosa. This enzyme catalyzes the conversion of nitrite to nitric oxide, which is involved in regulating cell growth and proliferation. The drug also inhibits epidermal growth factor-induced tyrosine phosphorylation and cellular proliferation in cultured human keratinocytes. MF 63 has also been shown to inhibit the growth of tumor cells derived from chronic lymphocytic leukemia and colon cancer cells. Synonyms: 2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile, 2-(9-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)- 1,3-Benzenedicarbonitrile CAS No: 892549-43-8 Molecular Formula: C23H11ClN4 Molecular Weight: 378.81 Purity: 98% Appearance: Crystalline solid Solubility: DMSO:PBS, pH 7.2 (1:2): 0.3mg/ml Melting Point: As Reported Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at RT. Reconstitute with solvent. Aliquot to avoid repeated freezing and thawing. Store at RT. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molekulargewicht:
378.81
CAS Nummer:
[892549-43-8]
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