A metabolite of Naltrexone (N285750). Methylnaltrexone (MNTX, M320350), a selective µ-opioid receptor (MOR) antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract. When opiates activate µ-opioid receptors (MORs) they trigger signaling pathways that lead to tolerance and hyperalgesia. Methylnaltrexone (M320350) is positively charged and therefore does not cross the blood brain barier. Mice given morphine with methylnaltrexone experienced pain relief without degeloping tolerance. Molecular Formula: C21H26BrNO4 Solubility: DMSO (Slightly), Methanol (Slightly) Molecular Weight: 436.34 Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
436.34
Formulierung:
Supplied as a Pale Pink to Pale Brown Solid
CAS Nummer:
[73232-52-7]
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