Isotope labeled Olaparib is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib has been shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy. Potent PARP inhibitor. Synonyms: 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone-d4, AZD 2281-d4, KU 0059436-d4, KU 59436-d4, 1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine-d4 CAS No: NA Molecular Formula: C24H19D4FN4O3 Molecular Weight: 438.49 Appearance: White to off-white powder Purity: 96% Isotopic Purity: ~99% NMR, F NMR, MS: Conforms to reference Solubility: Chloroform (Slightly), DMSO (Slightly) Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
438.49
Reinheit:
96%
Formulierung:
White to off-white powder
CAS Nummer:
[NA]
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