Upadacitinib also known as ABT-494, is a potent and selective Janus kinase (JAK) 1 inhibitor being developed for the treatment of several autoimmune disorders, Janus kinase inhibitors for rheumatoid arthritis. Synonyms: (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide, ABT-494 CAS No: 1310726-60-3 Molecular Formula: C17H19F3N6O Molecular Weight: 380.37 Purity(HPLC, TLC): 98% Appearance: Crystalline solid Solubility: DMSO:PBS (pH 7.2) (1:1): (0.50mg/ml) Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile DMSO:PBS. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molekulargewicht:
380.37
CAS Nummer:
[1310726-60-3]
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