EFNA1, also known as ephrin-A1 isoform a, is a member of the Ephrin-A family of GPI-anchored ligands. The Ephrin family receptor interacting proteins serve as the ligands of the Ephrin receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases. This protein contains on ephrin RBD (ephrin receptor-binding) domain. It is widely expressed on endothelial and epithelial a cells, particularly in the lung, intestine, liver, and skin. Also, this protein is expressed on resting CD4+ T cells inhibits cell proliferation and activation although soluble protein can promote T cell chemotaxis. Recombinant human EFNA1, fused to hIgG-His-Tag at C-terminal, expressed in Insect Cell and purified by using conventional chromatography techniques. Source: Recombinant protein corresponding to aa19-182 from human EFNA1, fused to hIgG-His-Tag at C-terminal, expressed in Insect Cell. Molecular Weight: ~46.6kD (331aa) ~40-57kD (SDS-PAGE under reducing conditions.) AA Sequence: ADPDRHTVFW NSSNPKFRNE DYTIHVQLND YVDIICPHYE DHSVADAAME QYILYLVEHE EYQLCQPQSK DQVRWQCNRP SAKHGPEKLS EKFQRFTPFT LGKEFKEGHS YYYISKPIHQ HEDRCLRLKV TVSGKITHSP QAHVNPQEKR LAADDPEVRV LHSIGHSLEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH Endotoxin: <1EU/1ug (LAL) Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
