SLX4 (Structure-Specific Endonuclease Subunit SLX4, SLX4 Structure-Specific Endonuclease Subunit Homolog (S. Cerevisiae)), Rabbit
Artikelnummer:
USB-492251
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| Artikelname: | SLX4 (Structure-Specific Endonuclease Subunit SLX4, SLX4 Structure-Specific Endonuclease Subunit Homolog (S. Cerevisiae)), Rabbit |
| Artikelnummer: | USB-492251 |
| Hersteller Artikelnummer: | 492251 |
| Alternativnummer: | USB-492251-100 |
| Hersteller: | US Biological |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | WB |
| Immunogen: | Synthetic peptide corresponding to the N-terminal region of human BTBD12 |
| This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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