VHL (Von Hippel-Lindau Disease Tumor Suppressor, Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase), Rabbit
Artikelnummer:
USB-495403
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| Artikelname: | VHL (Von Hippel-Lindau Disease Tumor Suppressor, Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase), Rabbit |
| Artikelnummer: | USB-495403 |
| Hersteller Artikelnummer: | 495403 |
| Alternativnummer: | USB-495403-100 |
| Hersteller: | US Biological |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | WB |
| Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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