Thrombomodulin, Recombinant, Human, aa22-515, His-Tag

Produktübersicht

• Artikelname: Thrombomodulin, Recombinant, Human, aa22-515, His-Tag
• Artikelnummer: USB-497083
• Hersteller Artikelnummer: 497083
• Alternativnummer: USB-497083-10,USB-497083-20,USB-497083-50,USB-497083-100,USB-497083-250
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

Thrombomodulin, also known as CD141 or BDCA-3, is an endothelial cell-expressed, transmembrane glycoprotein that can form a complex with the coagulation factor, thrombin. This complex induce activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. Thrombomodulin-bound thrombin has procoagulant effect at the same time by inhibiting fibrinolysis by cleaving thrombinactivatable fibrinolysis inhibitor (TAFI) into its active form. Reduced levels of thrombomodulin or increased serum levels of THBD can correlate with pathogenesis of certain cardiovascular diseases, such as atherosclerosis and thrombosis. In addition, It associated with liver cirrhosis, diabetes mellitus, cerebral and myocardial infarction, and multiple sclerosis. Recombinant protein corresponding to aa22-515 from human Thrombomodulin, fused to His-Tag at C-terminal, expressed in Baculovirus. Molecular Weight: ~52.6kD Amino Acid Sequence: EPQPGGSQCV EHDCFALYPG PATFLNASQI CDGLRGHLMT VRSSVAADVI SLLLNGDGGV GRRRLWIGLQ LPPGCGDPKR LGPLRGFQWV TGDNNTSYSR WARLDLNGAP LCGPLCVAVS AAEATVPSEP IWEEQQCEVK ADGFLCEFHF PATCRPLAVE PGAAAAAVSI TYGTPFAARG ADFQALPVGS SAAVAPLGLQ LMCTAPPGAV QGHWAREAPG AWDCSVENGG CEHACNAIPG APRCQCPAGA ALQADGRSCT ASATQSCNDL CEHFCVPNPD QPGSYSCMCE TGYRLAADQH RCEDVDDCIL EPSPCPQRCV NTQGGFECHC YPNYDLVDGE CVEPVDPCFR ANCEYQCQPL NQTSYLCVCA EGFAPIPHEP HRCQMFCNQT ACPADCDPNT QASCECPEGY ILDDGFICTD IDECENGGFC SGVCHNLPGT FECICGPDSA LARHIGTDCD SGKVDGGDSG SGEPPPSPTP GSTLTPPAVG LVHS Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 52.65
• NCBI: 000352
• UniProt: P07204
• Reinheit: 90% (SDS-PAGE). Endotoxin: 1EU/1ug (LAL)
• Formulierung: Supplied as a liquid in PBS, pH 7.4, 10% glycerol