TIM-3, Recombinant, Mouse, aa20-193, hIgG-His-Tag

Produktübersicht

• Artikelname: TIM-3, Recombinant, Mouse, aa20-193, hIgG-His-Tag
• Artikelnummer: USB-497085
• Hersteller Artikelnummer: 497085
• Alternativnummer: USB-497085-10,USB-497085-20
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

TIM-3, also known as HAVCR2 (Hepatitis A virus cellular receptor 2), belongs to TIM family cell surface receptor proteins. TIM-3 is up-regulated on several populations of activated myeloid cells and T cells. It is an immune checkpoint and together with other inhibitory receptors including PD-1and LAG3 mediate the CD8+ T-cell exhaustion. Also, it is primarily activated by galectin-9. The engagement leads to stimulation of an influx of calcium to intracellular space and induction of programmed cell death, apoptosis. As a consequence, a suppression of Th1 and Th17 responses and induction of immune tolerance occurs. Recombinant protein corresponding to aa20-193 from mouse TIM-3, fused to hIgG-His-Tag at C-terminal, expressed in HEK293 cells. Molecular Weight: ~46.3kD Amino Acid Sequence: RSLENAYVFE VGKNAYLPCS YTLSTPGALV PMCWGKGFCP WSQCTNELLR TDERNVTYQK SSRYQLKGDL NKGDVSLIIK NVTLDDHGTY CCRIQFPGLM NDKKLELKLD IKAAKVTPAQ TAHGDSTTAS PRTLTTERNG SETQTLVTLH NNNGTKISTW ADEIKDSGET IRTA Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 46.3413
• NCBI: 599011
• UniProt: Q8VIM0
• Reinheit: 95% (SDS-PAGE). Endotoxin: 1EU/1ug (LAL)
• Formulierung: Supplied as a liquid in PBS, pH 7.4, 10% glycerol.